RNA interference inC. elegans:History, application, and perspectives
نویسندگان
چکیده
منابع مشابه
RNA interference: Perspectives and caveats
RNA interference (RNAi) can still be regarded as a recently discovered phenomenon, but it has already made its way as a widely used method in molecular biology. In 1998, Andrew Fire and Craig Mello were the first to describe the mechanism of RNAi in the nematode C. elegans (Fire et al, 1998). Long double-stranded RNA molecules were found to mediate posttranscriptional silencing of genes with a ...
متن کاملEthical Perspectives on RNA Interference Therapeutics
RNA interference is a mechanism for controlling normal gene expression which has recently begun to be employed as a potential therapeutic agent for a wide range of disorders, including cancer, infectious diseases and metabolic disorders. Clinical trials with RNA interference have begun. However, challenges such as off-target effects, toxicity and safe delivery methods have to be overcome before...
متن کاملEnhancement of RNA Interference Effect in P19 EC Cells by an RNA-dependent RNA Polymerase
Background: RNA interference (RNAi) is a phenomenon uses double-stranded RNA (dsRNA) to specifically inhibit gene expression. The non-specific silencing caused by interferon response to dsRNA in mammalian cells limits the potential of utilizing RNAi to study gene function. Duplexes of 21-nucleotide short interfering dsRNA (siRNA) inhibit gene expression by RNAi. In some organisms, siRNA can als...
متن کاملA Randomized String Kernel and Its Application to RNA Interference
String kernels directly model sequence similarities without the necessity of extracting numerical features in a vector space. Since they better capture complex traits in the sequences, string kernels often achieve better prediction performance. RNA interference is an important biological mechanism with many therapeutical applications, where strings can be used to represent target messenger RNAs...
متن کاملRNA Interference and its Application in Crop Improvement
The discovery of RNA interference (RNAi) in mid-ninety’s added a new dimension in the regulation of gene expression by different types of RNA. It soon caught the worldwide attention and a number of reviews have been published to describe the RNAi phenomenon both in plants and animals. The technology became a powerful tool to understand the functions of individual genes and also proved useful fo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Integrative Biosciences
سال: 2007
ISSN: 1738-6357
DOI: 10.1080/17386357.2007.9647321